01 - Preheat oven to 400°F. Line a baking sheet with parchment paper or aluminum foil.
02 - In a small bowl, combine olive oil, Cajun seasoning, smoked paprika, salt, black pepper, garlic powder, onion powder, and cayenne pepper. Stir until a smooth paste forms.
03 - Pat the salmon fillets dry with paper towels. Arrange them skin-side down on the prepared baking sheet.
04 - Brush the Cajun spice mixture evenly over each fillet, coating the top and sides thoroughly.
05 - Bake for 12 to 15 minutes, until the salmon flakes easily with a fork and reaches an internal temperature of 145°F.
06 - Remove from the oven. Sprinkle with chopped parsley or cilantro and serve alongside lemon wedges.